As a historian of science Vavilov is widely known for his work on I. Newton and M. V. Lomonosov. He translated Newton's “Opticks” into Russian and supplied it with a commentary and notes, wrote a scientific biography of Newton and a book on the life and scientific work of Lomonosov, and more besides. In 1934 he founded the series “Classics of Science”. From 1938 he headed the Commission on the History of the USSR Academy of Sciences. He also gave considerable attention to the philosophical questions of natural science, arguing actively against the idealist conceptions of bourgeois philosophers and physicists. His works “Lenin and Modern Physics” and “The New Physics and Dialectical Materialism” are widely known. Vavilov had a talent for combining research with the wide popularisation of the achievements of science and the study of its history. His books “The Eye and the Sun” and “On Warm and Cold Light” and others, which became classics of Soviet popular-science literature, are models of popular scientific writing. He was one of the initiators of the Znanie Society and its first chairman (from 1947).
He did much for scientific publishing in the USSR as chairman of the Editorial and Publishing Council of the USSR Academy of Sciences (from 1945), editor-in-chief of the 2nd edition of the Great Soviet Encyclopedia (from 1949) and a member of the editorial boards of a number of series and journals. USSR State Prizes (1943, 1946, 1951). He founded a school of physicists (I. M. Frank, P. A. Cherenkov, S. N. Vernov, V. A. Fabrikant, P. P. Feofilov, E. I. Adirovich, N. A. Dobrotin, A. N. Sevchenko, M. N. Alentsev, V. V. Antonov-Romanovsky, A. M. Bonch-Bruevich, E. M. Brumberg, A. A. Vlasov, M. D. Galanin, L. V. Groshev, M. A. Konstantinova, V. L. Levshin, Z. L. Morgenstern, B. Ya. Sveshnikov, N. A. Tolstoy, V. S. Fursov, I. A. Khvostikov, A. A. Shishlovsky and others).
A member of a number of academies of sciences and scientific societies. In 1951 the Presidium of the USSR Academy of Sciences instituted the S. I. Vavilov gold medal.
The name of S. I. Vavilov has been given to the Institute of Physical Problems of the USSR Academy of Sciences and to the State Optical Institute.